Efficient and Selective Formation of Macrocyclic Distributed Z Alkenes
The first broadly applicable set of protocols for efficient Z-selective formation of macrocyclic disubstituted alkenes through catalytic ring-closing metathesis (RCM) is described.
ChemViews, 23 January 2013
Z-Selective Olefin Metathesis Reactions Promoted by Tungsten Oxo Alkylidene Complexes
New homogeneous catalysts show highly promising activity and selectivity for a large variety of olefin metathesis reactions.
JACS, 8 January 2013
Molybdenum-Based Complexes with Two Aryloxides and a Pentafluoroimido Ligand
Catalysts for Efficient Z-Selective Synthesis of a Macrocyclic Trisubstituted Alkene by Ring-Closing Metathesis
Angewandte Chemie, 8 January 2013
Enol Ethers as Substrates for Efficient Z- and Enantioselective Ring-Opening/Cross-Metathesis Reactions Promoted by Stereogenic-at-Mo Complexes. Utility in Chemical Synthesis and Mechanistic Attributes
The first examples of catalytic enantioselective ring-opening/cross-metathesis (EROCM) reactions that involve enol ethers are reported. Catalytic EROCM of several oxa- and azabicycles, cyclobutenes and a cyclopropene with an alkyl- or aryl-substituted enol ether proceed readily in the presence of a stereogenic-at-Mo monopyrrolide-monoaryloxide.
J Am Chem Soc., 8 February 2012
Z-Selective Metathesis for Macrocycles
Tungsten catalysts dictate stereochemistry of double bond
C&EN, 7 November 2011
Overcoming catalytic bias
Metathesis reactions can be used to make carbon-carbon double bonds - bar one isomeric class. By using new catalysts and balancing out the stabilities of intermediates in the reaction, the elusive isomers can be made.
Nature, 24 March 2011
Catalytic Z-selective olefin cross-metathesis for natural product synthesis
Here we report catalytic Z-selective cross-metathesis reactions of terminal enol ethers.
Nature, 24 March 2011
Organic Synthesis: Molybdenum catalyst generates less stable Z olefin.
C&EN, 28 March 2011
Endo-Selective Enyne Ring-Closing Metathesis Promoted by Stereogenic-at-W Mono-Pyrrolide Complexes
The utility of W-alkylidene complexes for enyne ring-closing metathesis is demonstrated in a direct comparison with Mo-based analogs. Tungsten complexes lead to less alkyne oligomerization and higher levels of endo-selectivity and enantioselectivity.
Org Lett., 18 February 2011